Pubblicazioni Patologia Molecolare e Cellulare

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Villa V, Marengo B, Cutolo CA, Passalacqua M, Vernazza S, Montalto G, Pronzato MA, Iester M, Ricciarelli R. 
Impact of anticancer drugs on human Tenon's fibroblast proliferation: implications for glaucoma surgery. 
BMJ Open Ophthalmol. 2026 Jan 12;11(1):e002307. doi: 10.1136/bmjophth-2025-002307. 
 
Agnifili L, Sacchi M, Figus M, Iester M, Pinna A, Posarelli C, Cassottana P, Corboli LV, Fornaro M, Palma A, Marotta A, di Nicola M, Mastropasqua L.
Sci Rep. 2026 Feb 9;16(1):7884. doi: 10.1038/s41598-026-39121-2. 
 
Forte P, Ferro Desideri L, Nassisi M, Milanesi F, Feo A, Bagnasco I, Iglesia SM, Forte G, Scandella D, Roccatagliata F, Fontana V, Eandi CM, Iester M, Jolly JK, Zinkernagel MS, Viola F, Nicolò M. 
Drusen-specific dark adaptation profiles in intermediate age-related macular degeneration. 
Int J Retina Vitreous. 2026 Feb 7;12(1):34. doi: 10.1186/s40942-025-00783-1. 
 
Forte P, Cattaneo J, Huang SC, Corazza P, Magnin S, Mangoni L, Ranno S, Cordano C, Polito A, Nicolò M, Iester M, Lupidi M, Eandi CM, Piccolino FC. 
Outer Retinal Erosion and Outer Retinal Pinching at the Origin of Subretinal Fluidin Central Serous Chorioretinopathy. 
Am J Ophthalmol. 2026 Feb 19:S0002-9394(26)00080-2. doi: 10.1016/j.ajo.2026.02.022.
 
Macri A, Tarallo M, Iester M. 
Imaging Approaches for the Diagnosis of Dry Eye: A Review. 
Diagnostics (Basel). 2026 Jan 1;16(1):126. doi: 10.3390/diagnostics16010126.  
 
Servillo A, Cutolo CA, Viganò C, Forte P, Manocchio R, Gazzard G, Rossetti L, Iester M, Oddone F, Virgili G, De Cillà S, Rabiolo A. 
Adherence of glaucoma intervention studies to World Glaucoma Association guidelines. 
Acta Ophthalmol. 2026 Feb 2. doi: 10.1111/aos.70070. 

Vagge A, Baldi M, Musolino M, Rivarone V, Catti C, Iester M. 
Current and Emerging Strategies for Myopia Control in Children: A Comprehensive Evidence-Based Review. 
J Clin Med. 2026 Feb 15;15(4):1545. doi: 10.3390/jcm15041545. 

NIHR Global Health Research Unit on Global Surgery. 
30-day postoperative mortality and the effects of hospital preparedness during the COVID-19 pandemic: a pooled analysis of prospective international cohort studies.
Lancet Reg Health Eur. 2026 Jan 29;62:101566. doi: 10.1016/j.lanepe.2025.101566.

Alfei S, Torazza C, Bacchetti F, Milanese M, Passalacqua M, Khaledizadeh E, Vernazza S, Domenicotti C, Marengo B.
Int J Mol Sci. 2025 May 22;26(11):4991. doi: 10.3390/ijms26114991. 

Alfei S, Torazza C, Bacchetti F, Signorello MG, Passalacqua M, Domenicotti C, Marengo B.
Tri-Phenyl-Phosphonium-Based Nano Vesicles: A New In Vitro Nanomolar-Active Weapon to Eradicate PLX-Resistant Melanoma Cells. 
Int J Mol Sci. 2025 Mar 30;26(7):3227. doi: 10.3390/ijms26073227. 

Brullo C, Marengo B, Domenicotti C, Lusardi M, Cichero E, Salis A, Caviglia D, Russo E, Spallarossa A. 
Triazole-imidazo[1,2-b]pyrazoles Able to Counteract Melanoma Cell Survival Without Compromising the Viability of Healthy Keratinocytes. 
Int J Mol Sci. 2025 Jun 30;26(13):6312. doi: 10.3390/ijms26136312. 

Pasino M, Speciale A, Ravera S, Cutrona G, Massara R, Bertola N, Viale M, Velkova I, Mazzarello AN, Fais F, Loiacono F, Matis S, Valenti GE, Traverso N, Domenicotti C, Marengo B, Tasso B, Ibatici A, Angelucci E, Vaisitti T, Monti P, Menichini P.
Targeting the p53/xCT/GSH Axis with PRIMA-1Met Combined with Sulfasalazine Shows Therapeutic Potential in Chronic Lymphocytic Leukemia.
Int J Mol Sci. 2025 Jun 10;26(12):5559. doi: 10.3390/ijms26125559. 

Grondona C, Marengo B, Valenti GE, Tirendi S, Russo E, Domenicotti C, Tasso B. 
Design and Synthesis of New Coumarin Hybrids Active Against Drug-Sensitive and Drug-Resistant Neuroblastoma Cells. 
Antioxidants (Basel). 2025 Dec 24;15(1):31. doi: 10.3390/antiox15010031. 

Pulliero A, Marengo B, Ferrante O, Khalid Z, Vernazza S, Ruzzarin N, Domenicotti C, Izzotti A. 
Antioxidant Food Supplementation in Cancer: Lessons from Clinical Trials and Insights from Preclinical Studies. 
Antioxidants (Basel). 2025 Oct 20;14(10):1261. doi: 10.3390/antiox14101261. 

Ponsaerts L, Alders L, Schepers M, Kemps H, Pirlet E, Willems E, De Bondt M, Jacobs R, Brullo C, Bruno O, Fedele E, Ricciarelli R, Prickaerts J, Somers V, Vandenbosch M, Vanmierlo T, Bronckaers A. 
Prophylactic PDE4 and PDE4B inhibition reduce lesion size and neutrophil infiltration following ischemic stroke in male mice. 
J Cereb Blood Flow Metab. 2025 Nov 3:271678X251386237. doi: 10.1177/0271678X251386237. 

Ricciarelli R. 
Erectile Dysfunction Drugs as Potential Therapy for Cognitive Decline: Preclinical and Translational Evidence. 
Cells. 2025 Sep 26;14(19):1505. doi: 10.3390/cells14191505. 

Schepers M, Vangansewinkel T, Libberecht K, Jeurissen H, Jacobs D, Piccart E, Prior R, Ricciarelli R, Brullo C, Fedele E, Bruno O, Prickaerts J, Lambrichts I, Van Den Bosch L, Vanmierlo T, Wolfs E. 
Phosphodiesterase 4D inhibition improves the functional and molecular outcome in a mouse and human model of Charcot Marie Tooth disease 1 A. 
Biomed Pharmacother. 2025 Feb;183:117828. doi: 10.1016/j.biopha.2025.117828. 

Barisione C, Ortona S, Ivaldo C, Righetti G, Pisa F, Mena Vera J M, Sartini M, Palombo D, Pigozzi S, Esposito D, Bastianon M, Paudice M, Vellone V G, Ortolan J, Giliberto L, d'Abramo C, Furfaro A L, Pratesi G, Nitti M.
AhR, IRF5, and HO-1 Expression in Evaluating Carotid Atherosclerotic Plaque Vulnerability: A Pilot Observational Study. 
Journal of the American Heart Association 2025, 14(10), e040911 doi: 10.1161/JAHA.124.040911. 

Carassa RG, Pomponio G, Agnifili L, Fea AM, Iester M, Marchini G, Martini E, Miglior S, Oddone F, Rossetti L, Sacchi M, Traverso CE, Figus M. 
Clinical recommendations for early identification of patients with open-angle glaucoma at higher risk of low adherence to topical treatment: An Italian Delphi consensus.
Acta Ophthalmol. 2025 Nov 17. doi: 10.1111/aos.70024. 

Catti C, Tessitore F, Ferrari D, Milanesi F, Acerra S, Peci L, Rizzi A, Semeria S, Schiavetti I, Cutolo CA, Iester M, Vagge A. 
Ocular movement abnormalities and ptosis after glaucoma surgery: A retrospective decade long analysis. 
PLoS One. 2025 Oct 30;20(10):e0335074. doi: 10.1371/journal.pone.0335074. 

Forte P, Feo A, Koizumi H, Borrelli E, Manocchio R, Di Cello L, Biagini F, Macocco F, Drago G, Forte G, Vagge A, Gianoglio C, Fontana V, Iester M, Nicolò M, Romano MR, Bonzano C. 
Scleral Thickness in Eyes with Pachychoroid Pigment Epitheliopathy Accompanied by Keratoconus. C.
Ophthalmol Sci. 2025 Apr 26;5(5):100808. doi: 10.1016/j.xops.2025.100808. 

Pazos M, Traverso CE, Viswanathan A; European Glaucoma Society; Guidelines Task Force; Guidelines Writers, Authors and Contributors; Guidelines Internal Reviewers; Experts by Experience group (patients’ panel); Team of Clinica oculistica of the university of Genoa for medical editing and graphics; External Reviews; EGS Executive Committee; Board of The EGS Foundation. European Glaucoma Society.
Terminology and guidelines for glaucoma, 6th Edition. 
Br J Ophthalmol. 2025 Sep 8;109(Suppl 1):1-212. doi: 10.1136/bjophthalmol-2025-egsguidelines. 

Trave I, Salvi I, Canameri R, Cutolo CA, Bonzano C, Baldi M, Bologna C, Drago G, Battaglia G, Parodi A, Iester M, Cozzani E. 
High Prevalence of Lash Collarettes in Patients with Atopic Dermatitis Treated with Dupilumab. 
Acta Derm Venereol. 2025 Aug 18;105:adv43322. doi: 10.2340/actadv.v105.43322. 

Valenti GE, Roveri A, Venerando R, Menichini P, Monti P, Tasso B, Traverso N, Domenicotti C, Marengo B.
PTC596-Induced BMI-1 Inhibition Fights Neuroblastoma Multidrug Resistance by Inducing Ferroptosis.
Antioxidants (Basel). 2024;13(1):3. doi: 10.3390/antiox13010003.
 
Schepers M, Hendrix S, Mussen F, van Breedam E, Ponsaerts P, Lemmens S, Hellings N, Ricciarelli R, Fedele E, Bruno O, Brullo C, Prickaerts J, Van Broeckhoven J, Vanmierlo T.
Neurotherapeutics. 2024 May 16;21(4):e00372. doi: 10.1016/j.neurot.2024.e00372.
 
Bertoncini-Silva C, Vlad A, Ricciarelli R, Giacomo Fassini P, Suen VMM, Zingg JM.
Enhancing the Bioavailability and Bioactivity of Curcumin for Disease Prevention and Treatment.
Antioxidants (Basel). 2024 Mar 8;13(3):331. doi: 10.3390/antiox13030331.
 
Barisione C, Verzola D, Garibaldi S, Altieri P, Furfaro AL, Nitti M, Pratesi G, Palombo D, Ameri P.
Cassottana P, Iester C, Bonzano L, Traverso CE, Iester M.
Quantitative evaluation of OCT angiography images in healthy and glaucomatous subjects through a novel approach: exploring inter-image variability.
Eye (Lond). 2024 Jul;38(10):1903-1907. doi: 10.1038/s41433-024-03038-9.
 
Sirito T, Cassottana P, Iester M, Laroni A.
Central serous chorioretinopathy in multiple sclerosis and its differential diagnosis with optic neuritis: a case report.
Neurol Sci. 2024 May 8. doi: 10.1007/s10072-024-07544-2.
 
Garbarino O, Valenti GE, Monteleone L, Pietra G, Mingari MC, Benzi A, Bruzzone S, Ravera S, Leardi R, Farinini E, Vernazza S, Grottoli M, Marengo B, Domenicotti C.
PLX4032 resistance of patient-derived melanoma cells: crucial role of oxidative metabolism.
Front Oncol. 2023 Jul 18;13:1210130. doi: 10.3389/fonc.2023.1210130.
 
Tirendi S, Marengo B, Domenicotti C, Bassi AM, Almonti V, Vernazza S.
Colorectal cancer and therapy response: a focus on the main mechanisms involved.
Front Oncol. 2023 Jul 19;13:1208140. doi: 10.3389/fonc.2023.1208140.
 
Alfei S, Milanese M, Brullo C, Valenti GE, Domenicotti C, Russo E, Marengo B.
Antiproliferative Imidazo-Pyrazole-Based Hydrogel: A Promising Approach for the Development of New Treatments for PLX-Resistant Melanoma.
Pharmaceutics. 2023 Oct 4;15(10):2425. doi: 10.3390/pharmaceutics15102425.
 
Valenti GE, Marengo B, Milanese M, Zuccari G, Brullo C, Domenicotti C, Alfei S.
Imidazo-Pyrazole-Loaded Palmitic Acid and Polystyrene-Based Nanoparticles: Synthesis, Characterization and Antiproliferative Activity on Chemo-Resistant Human Neuroblastoma Cells.
Int J Mol Sci. 2023 Oct 9;24(19):15027. doi: 10.3390/ijms241915027.
 
Ivaldo C, Passalacqua M, Furfaro AL, d’Abramo C, Ruiz S, Chatterjee PK, Metz CN, Nitti M, Marambaud P.
Oxidative stress-induced MMP- and γ-secretase-dependent VE-cadherin processing is modulated by the proteasome and BMP9/10.
Sci Rep. 2023 Jan 11;13(1):597. doi: 10.1038/s41598-022-27308-2.
 
Cutolo CA, Bonzano C, Catti C, Pizzorno C, Bagnis A, Traverso CE, Iester M.
Reoperations for complications within 90 days after gel stent implantation or trabeculectomy.
Int Ophthalmol. 2023 May;43(5):1745-1749. doi: 10.1007/s10792-022-02575-0.
 
Cassottana P, Toma C, Maltese C, Villa V, Ricciarelli R, Traverso CE, Iester M.
A Case of Bilateral Choroidal Effusion after XEN Gel Stent Implantation.
Gels. 2023 Mar 27;9(4):276. doi: 10.3390/gels9040276.
 
Montalto G, Ricciarelli R.
Tau, tau kinases, and tauopathies: An updated overview.
Biofactors. 2023 May-Jun;49(3):502-511. doi: 10.1002/biof.1930.
 
Paes D, Schepers M, Willems E, Rombaut B, Tiane A, Solomina Y, Tibbo A, Blair C, Kyurkchieva E, Baillie GS, Ricciarelli R, Brullo C, Fedele E, Bruno O, van den Hove D, Vanmierlo T, Prickaerts J.
Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology.
Cell Mol Life Sci. 2023 Jun 12;80(7):178. doi: 10.1007/s00018-023-04804-w.
 
Avitabile M, Bonfiglio F, Aievola V, Cantalupo S, Maiorino T, Lasorsa VA, Domenicotti C, Marengo B, Zbyněk H, Vojtěch A, Iolascon A, Capasso M.
Single-cell transcriptomics of neuroblastoma identifies chemoresistance-associated genes and pathways.
Comput Struct Biotechnol J. 2022 Aug 18;20:4437-4445. doi: 10.1016/j.csbj.2022.08.031.
 
Domenicotti C, Marengo B.
Paradox Role of Oxidative Stress in Cancer: State of the Art.
Antioxidants (Basel). 2022 May 23;11(5):1027. doi: 10.3390/antiox11051027.
 
Monteleone L, Marengo B, Musumeci F, Grossi G, Carbone A, Valenti GE, Domenicotti C, Schenone S.
Anti-Survival Effect of SI306 and Its Derivatives on Human Glioblastoma Cells.
Pharmaceutics. 2022 Jul 1;14(7):1399. doi: 10.3390/pharmaceutics14071399.
 
Valenti GE, Alfei S, Caviglia D, Domenicotti C, Marengo B.
Antimicrobial Peptides and Cationic Nanoparticles: A Broad-Spectrum Weapon to Fight Multi-Drug Resistance Not Only in Bacteria.
Int J Mol Sci. 2022 May 29;23(11):6108. doi: 10.3390/ijms23116108.
 
Furfaro AL, Loi G, Ivaldo C, Passalacqua M, Pietra G, Mann GE, Nitti M.
HO-1 Limits the Efficacy of Vemurafenib/PLX4032 in BRAFV600E Mutated Melanoma Cells Adapted to Physiological Normoxia or Hypoxia.
Antioxidants (Basel). 2022 Jun 14;11(6):1171. doi: 10.3390/antiox11061171.
 
Nitti M, Marengo B, Furfaro AL, Pronzato MA, Marinari UM, Domenicotti C, Traverso N.
Hormesis and Oxidative Distress: Pathophysiology of Reactive Oxygen Species and the Open Question of Antioxidant Modulation and Supplementation.
Antioxidants (Basel). 2022 Aug 19;11(8):1613. doi: 10.3390/antiox11081613.
 
Sindaco D, Cappelli F, Vagge A, Traverso CE, Iester M.
Ophthalmologic evaluation in vitamin-E deficiency: A case report.
Eur J Ophthalmol. 2022 Jan;32(1):NP254-NP257. doi: 10.1177/1120672120970112.
 
Cassottana P, Di Mola I, Ferro Desideri L, Vagge A, Cutolo CA, Traverso CE, Iester M.
Blood Reflux Through a PreserFlo MicroShunt Device After Needling.
J Glaucoma. 2022 Dec 1;31(12):979-981. doi: 10.1097/IJG.0000000000002091.
 
Burlando B, Losacco S, Villa V, Fedele E, Ricciarelli R.
A New Bistable Switch Model of Alzheimer’s Disease Pathogenesis.
Int J Mol Sci. 2022 Jun 25;23(13):7061. doi: 10.3390/ijms23137061.
 
Villa V, Montalto G, Caudano F, Fedele E, Ricciarelli R.
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue.
Biofactors. 2022 Sep;48(5):1111-1117. doi: 10.1002/biof.1847.
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