Pharmacology & Toxicology Publications

Selected Recent Publications

Taddeucci A, Torre V, Rosenwasser N, Saccani P, Olivero G, Bruno S, Giunti D, Uccelli A, Usai C, Pittaluga A. 
Acute "in vivo" LPS causes an early presynaptic C1q and C3 accumulation and increases the "prunability" of cortical synaptosomes. 
Neurochem Int. 2026 Mar 4:106132. doi: 10.1016/j.neuint.2026.106132. 

Tessitore S, Torazza C, Bonifacino T, Bacchetti F, Roselli F, Raiteri L, Milanese M, Bonanno G.
Focus on the excitatory and inhibitory neurotransmission imbalance in amyotrophic lateral sclerosis: a harmful disease player or a potential therapeutic opportunity?
Neurobiol Dis. 2026 Feb;219:107272. doi: 10.1016/j.nbd.2026.107272. 

Rosso F, Magdalena R, Torazza C, Bacchetti F, Milanese M, Poletti A, Bonanno G, Cristofani R, Bonifacino T.
Non-cell autonomous autophagy in amyotrophic lateral sclerosis: A new promising target?
Neurobiol Dis. 2026 Jan;218:107203. doi: 10.1016/j.nbd.2025.107203.

Raiteri L, Cerminara M, Puliti A, Pittaluga A.
Glycine Release Is Upregulated by Metabotropic Glutamate Receptor 1 in Mouse Hippocampus.
Biomedicines. 2025 Dec 17;13(12):3106. doi: 10.3390/biomedicines13123106.

Pittaluga A, Torre V, Olivero G, Rosenwasser N, Taddeucci A.
Non-canonical Roles of Complement in the CNS: From Synaptic Organizer to Presynaptic Modulator of Glutamate Transmission.
Curr Neuropharmacol. 2025;23(7):820-834. doi: 10.2174/011570159X327960240823065729.

Torre V, Marchese E, Willison E, Monaco M, Bozzo M, De Negri Atanasio G, Taddeucci A, Trebesova H, Rispo F, Rosenwasser N, Turrini F, Olivero G, Candiani S, Grasselli E, Marchese A, Alcaro S, Boggia R, Romeo I, Grilli M, Di Pilato V, Costa G, Pittaluga A.
Presynaptic release-regulating α2 receptors and Urolithins: A bridge between systemic EA administration and central health properties.
Biomed Pharmacother. 2025 Jul;188:118187. doi: 10.1016/j.biopha.2025.118187.

Monaco M, Torazza C, Fedele E, Grilli M.
The impact of the exposome on Alzheimer's disease.
Int J Mol Sci. 2025 Mar 26;26(7):3015. doi: 10.3390/ijms26073015.

Balbi M, Torazza C, Altosole T, Ravera S, Farinini E, Tessitore S, Bacchetti F, Rosso F, Musante I, Alfei S, Cerminara M, Puliti A, Filaci G, Fenoglio D, Leardi R, Fedele E, Bonanno G, Milanese M, Bonifacino T.
The complex phenotype and function of spinal cord microglia during ALS progression and the impact of metabotropic glutamate receptor type 5 down-regulation in SOD1G93A mice. 
Neurobiol Dis. 2025 Sep;213:107017. doi: 10.1016/j.nbd.2025.107017. 

Schepers M, Vangansewinkel T, Libberecht K, Jeurissen H, Jacobs D, Piccart E, Prior R, Ricciarelli R, Brullo C, Fedele E, Bruno O, Prickaerts J, Lambrichts I, Van Den Bosch L, Vanmierlo T, Wolfs E.
Phosphodiesterase 4D inhibition improves the functional and molecular outcome in a mouse and human model of Charcot Marie Tooth disease 1 A.
Biomed Pharmacother. 2025 Feb;183:117828. doi: 10.1016/j.biopha.2025.117828.

Bonifacino T, Mingardi J, Torazza C, Popoli M, Bonanno G, Milanese M, Musazzi L.
Psychotropic drug-dependent modulation of excitatory-inhibitory balance in the prefrontal cortex of rats exposed to acute footshock stress.
Eur Neuropsychopharmacol. 2025 Aug;97:12-13. doi: 10.1016/j.euroneuro.2025.06.006.

Farsetti E, Amato S, Averna M, Guidolin D, Pedrazzi M, Maura G, Agnati LF, Cervetto C, Marcoli M.
Dual Oxytocin Signals in Striatal Astrocytes.
Biomolecules. 2025 Aug 4;15(8):1122. doi: 10.3390/biom15081122.

Ravera S, Farsetti E, Maura G, Marcoli M, Bozzo M, Cervetto C, Amaroli A.
810-nm Photobiomodulation Evokes Glutamate Release in Normal and Rotenone-Dysfunctional Cortical Nerve Terminals by Modulating Mitochondrial Energy Metabolism.
Cells. 2025 Jan 7;14(2):67. doi: 10.3390/cells14020067.

Raiteri L.
Biomedicines 2024, 12(7), 1518; https://doi.org/10.3390/biomedicines12071518
 
Olivero G, Taddeucci A, Vallarino G, Trebesova H, Roggeri A, Gagliani MC, Cortese K, Grilli M, Pittaluga A.
 
Schepers M, Hendrix S, Mussen F, van Breedam E, Ponsaerts P, Lemmens S, Hellings N, Ricciarelli R, Fedele E, Bruno O, Brullo C, Prickaerts J, Van Broeckhoven J, Vanmierlo T.
Neurotherapeutics. 2024 May 16;21(4):e00372. doi: 10.1016/j.neurot.2024.e00372.
 
Valenza M, Facchinetti R, Torazza C, Ciarla C, Bronzuoli MR, Balbi M, Bonanno G, Popoli M, Steardo L, Milanese M, Musazzi L, Bonifacino T, Scuderi C.
Transl Psychiatry. 2024 May 25;14(1):209. doi: 10.1038/s41398-024-02928-6.
 
Raffaele S, Nguyen N, Milanese M, Mannella FC, Boccazzi M, Frumento G, Bonanno G, Abbracchio MP, Bonifacino T, Fumagalli M.
Br J Pharmacol. 2024 May 15. doi: 10.1111/bph.16408. Online ahead of print.
 
Bacchetti F, Schito AM, Milanese M, Castellaro S, Alfei S.
Int J Mol Sci. 2024 Feb 27;25(5):2761. doi: 10.3390/ijms25052761.
 
Amato S, Averna M, Farsetti E, Guidolin D, Pedrazzi M, Gatta E, Candiani S, Maura G, Agnati LF, Cervetto C, Marcoli M.Control of Dopamine Signal in High-Order Receptor Complex on Striatal Astrocytes.
Int J Mol Sci. 2024 Aug 7;25(16):8610. doi: 10.3390/ijms25168610. 
 
Parodi G, Zanini G, Collo L, Impollonia R, Cervetto C, Frega M, Chiappalone M, Martinoia S. 
In vitro electrophysiological drug testing on neuronal networks derived from human induced pluripotent stem cells. 
Stem Cell Res Ther. 2024 Nov 17;15(1):433. doi: 10.1186/s13287-024-04018-2.
 
Mingardi J, Ndoj E, Bonifacino T, Misztak P, Bertoli M, La Via L, Torazza C, Russo I, Milanese M, Bonanno G, Popoli M, Barbon A, Musazzi L.
Functional and Molecular Changes in the Prefrontal Cortex of the Chronic Mild Stress Rat Model of Depression and Modulation by Acute Ketamine.
Int J Mol Sci. 2023 Jun 28;24(13):10814. doi: 10.3390/ijms241310814.
 

Bonifacino T, Mingardi J, Facchinetti R, Sala N, Frumento G, Ndoj E, Valenza M, Paoli C, Ieraci A, Torazza C, Balbi M, Guerinoni M, Muhammad N, Russo I, Milanese M, Scuderi C, Barbon A, Steardo L, Bonanno G, Popoli M, Musazzi L.
Changes at glutamate tripartite synapses in the prefrontal cortex of a new animal model of resilience/vulnerability to acute stress.
Transl Psychiatry. 2023 Feb 18;13(1):62. doi: 10.1038/s41398-023-02366-w.

Cervetto C, Pistollato F, Amato S, Mendoza-de Gyves E, Bal-Price A, Maura G, Marcoli M.
Assessment of neurotransmitter release in human iPSC-derived neuronal/glial cells: a missing in vitro assay for regulatory developmental neurotoxicity testing.
Reprod Toxicol. 2023 Apr;117:108358. doi: 10.1016/j.reprotox.2023.108358. Epub 2023 Mar 1.

Amato S, Averna M, Guidolin D, Ceccoli C, Gatta E, Candiani S, Pedrazzi M, Capraro M, Maura G, Agnati LF, Cervetto C, Marcoli M.
Heteromerization of Dopamine D2 and Oxytocin Receptor in Adult Striatal Astrocytes.
Int J Mol Sci. 2023 Feb 28;24(5):4677. doi: 10.3390/ijms24054677.

Fedele E.
Anti-Amyloid Therapies for Alzheimer’s Disease and the Amyloid Cascade Hypothesis.
Int J Mol Sci. 2023 Sep 24;24(19):14499. doi: 10.3390/ijms241914499.
 
Schepers M, Paes D, Tiane A, Rombaut B, Piccart E, van Veggel L, Gervois P, Wolfs E, Lambrichts I, Brullo C, Bruno O, Fedele E, Ricciarelli R, Ffrench-Constant C, Bechler ME, van Schaik P, Baron W, Lefevere E, Wasner K, Grünewald A, Verfaillie C, Baeten P, Broux B, Wieringa P, Hellings N, Prickaerts J, Vanmierlo T.
Selective PDE4 subtype inhibition provides new opportunities to intervene in neuroinflammatory versus myelin damaging hallmarks of multiple sclerosis.
Brain Behav Immun. 2023 Mar;109:1-22. doi: 10.1016/j.bbi.2022.12.020.
 
Torazza C, Provenzano F, Gallia E, Cerminara M, Balbi M, Bonifacino T, Tessitore S, Ravera S, Usai C, Musante I, Puliti A, Van Den Bosch L, Jafar-Nejad P, Rigo F, Milanese M*,Bonanno G.
Genetic Downregulation of the Metabotropic Glutamate Receptor Type 5 Dampens the Reactive and Neurotoxic Phenotype of Adult ALS Astrocytes.
Cells. 2023 Jul 27;12(15):1952. doi: 10.3390/cells12151952.

Forti L, Ndoj E, Mingardi J, Secchi E, Bonifacino T, Schiavon E, Carini G, La Via L, Russo I, Milanese M, Gennarelli M, Bonanno G, Popoli M, Barbon A, Musazzi L.
Dopamine-Dependent Ketamine Modulation of Glutamatergic Synaptic Plasticity in the Prelimbic Cortex of Adult Rats Exposed to Acute Stress.
Int J Mol Sci. 2023 May 13;24(10):8718. doi: 10.3390/ijms24108718.
 
Olivero G, Grilli M, Marchi M, Pittaluga A.
Metamodulation of presynaptic NMDA receptors: New perspectives for pharmacological interventions.
Neuropharmacology. 2023 Aug 15;234:109570. doi: 10.1016/j.neuropharm.2023.109570. 

Roggeri A, Olivero G, Usai C, Vanmierlo T, Pittaluga A.
Presynaptic Release-Regulating Sphingosine 1-Phosphate 1/3 Receptors in Cortical Glutamatergic Terminals: Adaptations in EAE Mice and Impact of Therapeutic FTY720.
Cells. 2023 Sep 24;12(19):2343. doi: 10.3390/cells12192343.
 
Iovino L, Giusti V, Pischedda F, Giusto E, Plotegher N, Marte A, Battisti I, Di Iacovo A, Marku A, Piccoli G, Bandopadhyay R, Perego C, Bonifacino T, Bonanno G, Roseti C, Bossi E, Arrigoni G, Bubacco L, Greggio E, Hilfiker S, Civiero L.
Trafficking of the glutamate transporter is impaired in LRRK2-related Parkinson’s disease.
Acta Neuropathol. 2022 Jul;144(1):81-106. doi: 10.1007/s00401-022-02437-0.
 
Bonifacino T, Micheli L, Torazza C, Ghelardini C, Farina C, Bonanno G, Milanese M, Di Cesare Mannelli L, Scherz MW.
Cells. 2022 Dec 13;11(24):4027. doi: 10.3390/cells11244027.
 
Amato S, Averna M, Guidolin D, Pedrazzi M, Pelassa S, Capraro M, Passalacqua M, Bozzo M, Gatta E, Anderlini D, Maura G, Agnati LF, Cervetto C, Marcoli M.
Heterodimer of A2A and Oxytocin Receptors Regulating Glutamate Release in Adult Striatal Astrocytes.
Int J Mol Sci. 2022 Feb 19;23(4):2326. doi: 10.3390/ijms23042326. 

Marcoli M, Cervetto C, Amato S, Fiorucci C, Maura G, Mariottini P, Cervelli M.
Transgenic Mouse Overexpressing Spermine Oxidase in Cerebrocortical Neurons: Astrocyte Dysfunction and Susceptibility to Epileptic Seizures.
Biomolecules. 2022 Jan 25;12(2):204. doi: 10.3390/biom12020204.

Villa V, Montalto G, Caudano F, Fedele E, Ricciarelli R.
Selective inhibition of phosphodiesterase 4D increases tau phosphorylation at Ser214 residue.
Biofactors. 2022 Sep;48(5):1111-1117. doi: 10.1002/biof.1847.

 
Sala N, Paoli C, Bonifacino T, Mingardi J, Schiavon E, La Via L,  Milanese M , Tornese P, Datusalia AK, Rosa J, Facchinetti R, Frumento G, Carini G, Salerno Scarzella F, Scuderi C, Forti L, Barbon A, Bonanno G, Popoli M, Musazzi L.
Acute Ketamine Facilitates Fear Memory Extinction in a Rat Model of PTSD Along With Restoring Glutamatergic Alterations and Dendritic Atrophy in the Prefrontal Cortex.
Front Pharmacol. 2022 Mar 17;13:759626. doi: 10.3389/fphar.2022.759626. eCollection 2022.

Provenzano F, Nyberg S, Giunti D, Torazza C, Parodi B, Bonifacino T, Usai C, Kerlero de Rosbo N, Milanese M*, Uccelli A, Shaw PJ, Ferraiuolo L, Bonanno G.
 
 
Fagiani F, Baronchelli E, Pittaluga A, Pedrini E, Scacchi C, Govoni S, Lanni C.

Taddeucci A, Olivero G, Roggeri A, Milanese C, Giorgio FPD, Grilli M, Marchi M, Garrone B, Pittaluga A.
Presynaptic 5-HT2A-mGlu2/3 Receptor-Receptor Crosstalk in the Prefrontal Cortex: Metamodulation of Glutamate Exocytosis.
Cells. 2022 Sep 28;11(19):3035. doi: 10.3390/cells11193035. 
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